In this project, we studied the effect of the BDNF Val66Met SNP on outcomes after repeated mild traumatic brain injury and used AAV-BDNF as a personalized treatment approach.
Feel free to read more about it here:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854037/pdf/fneur-10-01175.pdf
Our previous work studied proBDNF and mature BDNF signaling after single moderate TBI, and used small molecule therapy targeting these signaling pathways as therapy.
You can read more about it here: